DRDO's 2-DG Drug To Be Launched Next Week
The primary group of DRDO drug '2-DG' will be given its underlying dispatch with 10,000 portions one week from now. Educating about this, DRDO authorities said that they increase creation for its future use in the treatment of Covid patients. This medication has been made by a group of DRDO researchers, including Dr. Anant Narayan Bhatt.
"The primary cluster of 10,000 portions of 2-DG medication for the treatment of Covid-19 contaminated patients would be dispatched right on time one week from now and will be given to patients," a DRDO official was cited as saying.
What is the 2-DG and Which organization has created it?
The 2-DG is a 2-deoxy-D-glucose drug that will be given as an enemy of Covid-19 remedial application. It will be given as an extra treatment or an elective treatment, and its motivation is to help the essential treatment. It comes in powder structure in sachets, which is to be taken orally by dissolving in water.
It has been created by the Institute of Nuclear Medicine and Allied Sciences (INMAS), a lab of Defense Research and Development Organization (DRDO), in a joint effort with Dr Reddys Laboratories (DRL), Hyderabad.
How does 2DG assistance in the treatment of Covid patients?
The Clinical preliminary aftereffects of the 2-DG drug have shown that this particle helps in quicker recuperation of hospitalized patients and decreases supplemental oxygen reliance. A higher extent of patients treated with 2-DG showed RT-PCR negative change in Covid patients. DRDO has expressed that the medication would be good for individuals experiencing Covid-19.
"The medication is relied upon to save valuable lives because of the instrument of activity of the medication in tainted cells. This likewise diminishes the emergency clinic stay of COVID-19 patients," the protection service had expressed.
How does 2DG diminish Oxygen reliance?
The 2 DG drug is said to deal with infection contamination spread into lungs which can assist specialists with diminishing patients constancy on oxygen.
"It collects in the infection contaminated cells and forestalls infection development by halting viral amalgamation and energy creation. Its particular gathering in virally tainted cells makes this medication one of a kind," the service had said upon endorsement.
When and how did testing of 2DG medication happen?
In April 2020, during the primary rush of the Coronavirus pandemic, INMAS-DRDO researchers led lab explores different avenues regarding the assistance of the Center for Cellular and Molecular Biology (CCMB), Hyderabad, and tracked down that this atom works adequately against the SARS-CoV-2 infection and represses the viral development.
In light of these outcomes, the Drugs Controller General of Indias (DCGI) Central Drugs Standard Control Organization (CDSCO) is said to have allowed Phase-2 clinical preliminary of 2-DG in Covid-19 patients in May 2020.
The DRDO, alongside its industry accomplice DRL in Hyderabad, begun clinical preliminaries to test the wellbeing and adequacy of the medication in Covid-19 patients.
Stage 2 preliminaries which included portion running were directed during May-October 2020 and the medication was discovered to be protected in Coronavirus patients. It showed huge improvement in their recuperation, Phase-2 was led in six emergency clinics on 110 patients and Phase 2b (portion running) clinical preliminary was led at 11 clinics the nation over.
What have Phase 3 preliminaries finished up?
In light of victories, DCGI permitted Phase-3 clinical preliminaries in November 2020. Stage 3 clinical preliminaries were led on 220 patients between December 2020 to March 2021 out of 27 Covid medical clinics in Delhi, Uttar Pradesh, West Bengal, Gujarat, Rajasthan, Maharashtra, Andhra Pradesh, Telangana, Karnataka and Tamil Nadu.
Nitty gritty information of Phase 3 clinical preliminary were introduced to DCGI. A huge improvement was seen in side effects experienced by patients. A comparable pattern was found in patients more established than 65 years.
Other than the 2DG, DRDO has concocted another imaginative arrangement called the Oxycare System which enhances the utilization of oxygen and diminishes the responsibility and openness of medical care suppliers by disposing of the need to regularly gauge and make manual acclimations to oxygen stream.
The Chemistry of Corona drug developed by DRDO is said to be a big game changer. It is 2-Deoxy-D+Glucose (2-DG) which is likely to be marketed very soon. The hero behind this discovery is said to be the Scientist, Dr. Anil Kumar Mishra who obtained his M.Sc.(Chemsitry) degree from Gorakhpur University in 1984 and Ph.D degree in 1988 from Banaras Hindu University. His research is mainly based on Molecular Biology and Organic synthesis. After doing the post doctoral research, he has worked as visiting Professor in different foreign countries like France, California (USA) and Max Plank, Germany. He joined DRDO as Sr. Scientist in the year 1997.
2-DG is a mimic of D-Glucose prepared by replacing -OH group at C2 by H-atom. Hence, the name 2-Deoxy-D-Glucose meaning removal of oxygen from 2nd carbon. Being mimic of D- Glucose, it gets easy passage into the cells where Corona virus is already present.
Glucose breaks down into two three carbon compounds one of them being pyruvate anion (CH3COCOO-) with release of energy. It is a metabolic process called Glycolysis. It is this energy on which all living organism survive. Corona virus also survives on this energy. Unlike D-Glucose, 2-DG is unfit for glycolysis.No energy is evolved. The sustaining of life becomes difficult and as such Corona virus dies within a week in want of energy. It is said that this drug also lowers the oxygen dependence of patients.This drug is also antitumour/anticancer by the same mechanism.If it is able to destroy killer Corona virus, crores of precious lives will be saved.Thank you DRDO.
The science behind the 2DG drug for Covid-19 developed by DRDO: 10,000 doses of 2DG by DRDO is expected to be released next week ! Hopefully, Mass-scale production is ramping up will start soon at Hyderabad and likely at other centers! The principle of operation is simple: "Cheat the Cheater"! You know that any virus, once inside the body, makes its own copies by cheating our human cells and takes their protein to multiply itself! The brilliant thought process by Indian scientists was simple! For every doubling of virus cell, it needs energy (glucose!). So, the medicine is simply a "Pseudo" Glucose which the multiplying virus intakes but actually, this glucose makes it neuter (unable to multiply!). Thus 'Cheating the cheater' once the rapid multiplication of virus is halted, our own anti bodies can readily combat it and overpower within hours! Simply Genius ! Be proud of Indian scientists!