DPT Vaccine -Diphtheria, tetanus, and pertussis vaccine

DPT Vaccine -Diphtheria, tetanus, and pertussis vaccine

(i) What is tetanus diphtheria and pertussis?

Tetanusdiphtheria, and pertussis (whooping cough) are serious bacterial infections. Tetanus causes painful tightening of the muscles, usually all over the body. It can lead to “locking” of the jaw. Diphtheria usually affects the nose and throat.
Whooping cough causes uncontrollable coughing. Vaccines can protect you from these diseases. In the U.S., there are four combination vaccines:

(ii) What is in the DTaP vaccine? Dtap vaccine ingredients.

Each 0.5-mL dose of Adacel® (Sanofi Pasteur) contains 5 Lf tetanus toxoid, 2 Lf diphtheria toxoid, and acellular pertussis antigens (2.5 µg detoxified PT, 5 µg FHA, 3 µg pertactin, 5 µg FIM).

(iii) DPT Vaccine provides protection against?

DPT Vaccine provide protection against Diphtheria, tetanus, and pertussis caused by Cornybacterium diptherai, Bordetella pertussis and Clostridium tetani respectively

(iv) Do you need Tdap if you had DTaP?

Since the first DTaP was received before 12 months of age and one Tdap dose has been given, this person needs one dose of Td or Tdap 6 calendar months after the Tdap dose.
A routine Td or Tdap booster should be administered every 10 years.

(v) What is the difference between DTaP and Tdap?

DTaP is approved for children under age 7. 
Tdap, which has less amount of dose of diphtheria and pertussis vaccines, is approved for children from age 11 and adults ages 19 to 64.
It is usually also called a booster dose because it boosts the immunity that wanes from vaccines are given at ages 4 to 6.

(vi) Diphtheria, tetanus, and pertussis vaccine DPT vaccine India .

The followings of the and Diptheria, tetanus pertussis vaccine an available in India
• Diphtheria, tetanus, and whole-cell pertussis vaccine. commonly know as triple antigen. Different combination of DTwp are available such as

— Quadrivalent (DTwp + Hib)
– Pentavalent (DTwp + Hib+ HB)
– Hexavalent (DTwp + Hib+ HB+ IPV)
• DTaP Diphtheria, tetanus, and acellular pertussis vaccine
•Different combinations of DTaP vaccines are avilable such as
– Pentavalent( DTAP + Hib +HB)
-Hexavalent (DTaP+Hib + HB +IPV
• Tdap Diphtheria, tetanus, and acellular vaccine (reduced antigen content
• DT : Diphtheria and tetanus vaccine
•Td Diphtheria (reduced-dose) and tetanus vaccine

(vii) DPT Vaccine side effects .

Mild adverse events
Fever, irritability, drowsiness, loss of appetite and vomiting
Severe adverse effects
Hight fever, persistent crying, hypotonic, hyporesponsive, episode (HHE)
Encephalopathy, Dravet syndrome, anaphylaxis and Guillain barre syndrome (GBS)

Dpt vaccine route

0.5 mL administered IM anterolateral thigh or deltoid

(viii) DPT Vaccine Schedule

• Primary 3 doses at 6 ,10, 14 weeks
•First booster 15-18 months
•2nd booster: 4 to 6 months
• Tdap /Td 10-12 years. 16 years

If missed the DPT Vaccine ( Gap in the series)
•complete the series
•Do not restart

Below 7 years
• DTwP/ DTaP 0,1 ,2,6 MONTHS
2nd booster not required if last dose administered at >4 years

Above 7 years
•Tdap 0 dose then Td 1, 6 months
•Td every 10 years after this 11-18years
•Tdap 1 dose
•Later Td every 10 years

(ix)Special comments

•DTaP may be preferred to DTwP in children with a history of severe adverse effects after the previous dose of DTwP or children with neurological disorders.
• DTwP/DTaP vaccine must not be used in children in 7 years or older because of increased reactogenicity (Use Tdap/Td instead )
•In principle the same type of wp/Ap containing vaccine should be given.
throughout the primary source of vaccination. However, if the previous type of vaccine is unknown or unavailable any wp/ap may be used for subsequent doses.

(x) Type of Vaccine

With whole cell pertussis(wp) vaccine or acellular pertussis vaccine(aP)